Accurate detection
Simple and fast operation
Blood card direct expansion
Easy-to-read results
Provide an overall solution
Accurate detection
Simple and fast operation
Blood card direct expansion
Easy-to-read results
Provide an overall solution
Thrombophilia is a tendency of the body to form high blood clots, which is caused by hereditary or acquired defects of anticoagulant proteins, coagulation factors, fibrinolytic proteins, etc., and mainly occurs as venous thrombosis. Nearly 10 million cases occur worldwide every year, with more than 800,000 deaths, making it the third-ranked vascular killer in the world.
Studies have shown that about 60% of individual differences in susceptibility to venous thrombosis are due to genetic factors. Gene mutation is the main factor causing hereditary thrombophilia, which can be divided into two categories: anticoagulant factor gene mutation and coagulation factor gene mutation. Caused by mutations in the prothrombin G20210A gene, and hereditary thrombophilias caused by mutations in genes of this coagulation factor (F5 Leiden and F2 G20210A) are more common in the Caucasian population, while other defects associated with increased coagulation include Factor F7 and F13 gene mutations and homocysteine gene mutations (MTHFR, MTR, and MTRR).
In addition, studies have shown that hereditary thrombophilia caused by anticoagulant factor gene mutations accounts for about 12.9% of VTE patients, of which antithrombin gene (PAI1) mutations account for 0.5%, resulting in decreased antithrombin activity. In addition to hereditary thrombophilia caused by common anticoagulant proteins and coagulation factor-related genes, mutations in fibrinolytic protein-related genes (FGB) and platelet coagulation function-related genes (ITGA2 and ITGB3) can also change the coagulation function of the body. Increased risk of blood clots in the body. The genetic variation of each of these genes will affect the normal blood coagulation function of the body, resulting in thrombotic events that significantly increase the morbidity and mortality of patients and seriously endanger human health.
1. PCR machine
2. Genetic Analyzer (Zhiyue Genetic Analyzer or ABI Series Genetic Analyzer)
EDTA/sodium citrate anticoagulant blood, blood traces stored in blood card, DNA
